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A method for treating multiple sclerosis (MS) comprising administering to a subject with MS a drug that causes an increase in the level of a gene product selected from the group consisting of those genes indicated by a minus (-) sign in Tables 1-12.46.
A method for treating multiple sclerosis (MS) comprising administering to a subject with MS a drug that causes a decrease in the level of a gene product selected from the group consisting of those genes indicated by a plus ( ) sign in Tables 1-12 and 16. 60/379,284, filed May 9, 2003, the entire contents of which are hereby incorporated by reference. Field of the Invention The present invention relates generally to the fields of molecular biology, genomics, immunology and neurobiology.
This is difficult not only because of the lack of a definitive biological test for MS, but because the symptoms may overlap with those of numerous other diseases.
Despite these individual associations, there has yet to be put forth a cohesive set of genes that, as a group, provide accurate diagnostic or prognostic information regarding MS.
Thus, there remains a need for a genetic based test that identifies individuals having or at risk of developing MS.
Although no single gene is associated with all types of MS, several reports have revealed that some genes are associated with MS in certain populations.
The well known HLA association with MS has been demonstrated in populations of northern European ancestry.
The method may further comprise determining expression information for one or more genes in Tables 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12.